Mexican · Madre Mezcal
Swap the tequila for mezcal and the paloma changes completely. Mezcal is made from agave roasted in earth pits, so it carries smoke, and smoke against grapefruit is one of the best pairings in the whole cocktail canon.

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The one thing that matters
Madre's espadin is soft as mezcals go, so it will not take over the drink. Use a proper grapefruit soda, not diet, and be generous with the salt.
Yes, and many people prefer it. The smoke from the roasted agave plays against the bitterness of the grapefruit in a way tequila cannot. Start with a softer espadin like Madre before you try anything heavier.
Tequila must be blue agave and the agave is steamed. Mezcal can be many agave varieties and the hearts are roasted in earth pits, which is where the smoke comes from. All tequila is technically mezcal; not all mezcal is tequila.